the effects of eucheuma cottonii on alveolar macrophages and malondialdehyde levels in bronchoalveolar lavage fluid in chronically particulate matter 10 coal dust-exposed rats

objective(s):to investigate the effect of eucheuma cottonii on alveolar macrophages (am) and malondialdehyde (mda) levels in bronchoalveolar lavage fluids (balf) in particulate matter 10 (pm10) coal dust-exposed rats. materials and methods: ten groups, including a non exposed group and groups exposed to coal dust at doses of 6.25 (cd6.25), 12.5 (cd12.5), or 25 mg/m3 (cd25) an hour daily for 6 months with or without supplementation of ethanolic extract of e. cottonii at doses of 150 (ec150) or 300 mg/kg bw (ec300). the number of macrophages was determined using a light microscope. mda levels were measured by tbars assay. results: ec150 insignificantly (p > 0.05) reduces the am in cd groups compared to non treatment groups. ec150 and ec300 significantly (p < 0.05) decreased mda levels in cd12.5 and cd25 groups relative to non treatment groups. conclusion: e. cottonii attenuated oxidative stress in chronic exposure of pm10 coal dust.